Normal human B cells display ordered light chain gene rearrangements and deletions.
نویسندگان
چکیده
منابع مشابه
Normal human B cells display ordered light chain gene rearrangements and deletions
Human kappa-producing B cell lines and leukemias retain their excluded lambda light chain genes in the germ line configuration, whereas transformed lambda-producing B cells uniformly rearrange or delete their kappa genes (12). Whether the unexpected lambda gene recombinations within malignant lambda-producing B cells reflect a normal developmental process or are secondary to transformation and ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1982
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.156.4.975